Endocrine Abstracts

Prolonged spontaneous remission of hypercortisolemia in ectopic ACTH syndrome after long-term treatment with steroidogenesis inhibitors has been described. Direct drug effect on the adrenal glands, effects on tumoral ACTH secretion and/or POMC gene expression have been suggested. Medical treatment could be used for symptoms, but also for disease control.Materials and methods: In human BON-1 and DMS-79 cells, we have evaluated the effects of keto...

Lipid profile suffers adaptive changes during pregnancy due to estrogen stimulation and insulin resistance. Several relations have been suggested between maternal lipid profile, glucose tolerance, endothelial cell dysfunction and long-term cardiovascular risk; the effects of maternal lipid profile metabolism in fetal growth are also inconclusive. Since a regular evaluation and follow-up of lipid profile during pregnancy has not been stablished yet, we aimed to evaluate the inc...

Objective: Cushing’s disease (CD) is the most common cause of hypercortisolism after iatrogenic origin, it represents approximately 70% of patients with endogenous Cushing’s syndrome (CS) and ectopic ACTH secretion (10%). CD is caused by a corticotropin-secreting pituitary neuroendocrine tumor (ACTH-secreting Pit-NETs), 95% of cases as a microadenoma. In ACTH-dependent CS, differential diagnosis between CD and ectopic CS must be established. 40% of CD cases, any tumo...

Objective: To evaluate the nutritional status in patients with type 1 diabetes mellitus (DM1) or latent autoimmune diabetes in adults (LADA).Methods: Observational transversal clinical study in patients with DM1/LADA. Nutritional assessment was performed using bioelectrical impedance analysis (BIA), dynamometry, ultrasound of rectus femoris muscle and subcutaneous fat tissue, functional tests and laboratory parameters. Statistical analysis was performed ...

Aim: To describe the follow-up of adrenal incidentalomas (AI) classified as non-functioning and no suspicious for malignancy in the first approach.Patients and methods: Observational retrospective study of a cohort of patients who consulted in the Endocrinology service between 2005 and 2015 because of an AI. Statistical analysis performed with SPSS 19th version.Results: Two hundred and one patients with IA were firstly evaluated. T...

Aim: To describe the prevalence of abnormal glucose tolerance and diabetes in patients with cystic fibrosis (CF) depending on the diagnostic criteria.Methods: Observational, cross-sectional, clinical research on patients with CF evaluated at Hospital Universitario Reina Sofía (Córdoba).Results: Twenty-eight patients were selected for the study. Age: 31.85±8.78 years, with a CF evolution time of 21.77±9.37 years....

Background: Malnutrition affects 30-50% of patients with hematological malignancies; it is due to the disease itself, the treatment-related catabolic process and chemo-or radio-therapy side effects (nausea, vomiting, diarrhea and mucositis). Patients with poor nutritional status have increased morbidity (treatment complications, infections, mucositis) and mortality.AimTo evaluate the nutritional status of all patients that underwent hematopoietic stem ce...

Aim: Evaluate results of bariatric surgery by using the Bariatric analysis and reporting outcome system (BAROS) scoring systemPatients and methods: Observational clinical study of consecutive cases of patients undergoing bariatric surgery in Reina Sofia University Hospital (Córdoba, Spain) and clinical follow-up in the Endocrinology service between January and December 2018. Statistical analysis performed with SPSS 24th version.<p class="abstext...

Introduction: Non-functioning pituitary adenomas (NFPAs) represent the most common pituitary tumour. They usually appear in the middle age of life, without differences between genders. Mass growth produces the first symptoms so the diagnosis is usually late. Surgery is the first-line treatment with variable success (19-83%). The objective of this study is to evaluate the symptoms, diagnosis, treatment and final state of patients with NFPAs.Methods: Obser...

Neuroendocrine tumors (NETs) are uncommon neoplasms with increasing incidence and limited therapeutic options, wherein identification of new diagnostic/prognostic/therapeutic biomarkers is urgently required. Alterations in somatostatin (SST)/cortistatin (CORT) and ghrelin systems have been associated to development/progression of several cancers. Thus, we evaluated expression levels of SST/CORT/ghrelin system components in gastroenteropancreatic-neuroendocrine tumors (GEP-NETs...